The TIU found that the Egyptian, 21, had committed 21 breaches of anti-corruption rules between 2015 and 2019.
It also ruled he conspired with others to carry out betting-related corruption at the lower levels of the sport.
Hossam reached a career-high singles ranking of 291 in December 2017 and is currently ranked 820.
He was provisionally suspended from tennis in May last year and was found to have committed eight cases of match-fixing, six cases of facilitating gambling and two cases of soliciting other players not to use their best efforts.
He was also found guilty of three failures to report corrupt approaches and two failures to co-operate with a TIU investigation.
"As a result of his conviction, Mr Hossam is now permanently excluded from competing in or attending any sanctioned tennis event organised or recognised by the governing bodies of the sport," said a TIU statement.
His elder brother, Karim Hossam, was banned from tennis for life for multiple match-fixing offences in 2018.